منابع مشابه
Deficiency of senescence marker protein 30 exacerbates angiotensin II-induced cardiac remodelling.
AIMS Ageing is an important risk factor of cardiovascular diseases including heart failure. Senescence marker protein 30 (SMP30), which was originally identified as an important ageing marker protein, is assumed to act as a novel anti-ageing factor in various organs. However, the role of SMP30 in the heart has not been previously explored. In this study, our aim was to elucidate the functional ...
متن کاملDeficiency of Senescence Marker Protein 30 Exacerbates Cardiac Injury after Ischemia/Reperfusion
Early myocardial reperfusion is an effective therapy but ischemia/reperfusion (I/R) causes lethal myocardial injury. The aging heart was reported to show greater cardiac damage after I/R injury than that observed in young hearts. Senescence marker protein 30 (SMP30), whose expression decreases with age, plays a role in reducing oxidative stress and apoptosis. However, the impact of SMP30 on myo...
متن کاملAlveolar cell senescence exacerbates pulmonary inflammation in patients with chronic obstructive pulmonary disease.
BACKGROUND Alveolar cell senescence is accelerated in patients with chronic obstructive pulmonary disease (COPD). OBJECTIVES We tested the hypothesis that alveolar cell senescence contributes to the chronic inflammation that affects the lungs of COPD patients. METHODS We exposed alveolar type II-like epithelial (A549) cells to a G-quadruplex-interacting telomerase inhibitor in vitro to indu...
متن کاملEpithelial cell senescence impairs repair process and exacerbates inflammation after airway injury
BACKGROUND Genotoxic stress, such as by exposure to bromodeoxyuridine (BrdU) and cigarette smoke, induces premature cell senescence. Recent evidence indicates that cellular senescence of various types of cells is accelerated in COPD patients. However, whether the senescence of airway epithelial cells contributes to the development of airway diseases is unknown. The present study was designed to...
متن کاملHypoxia Exacerbates Negative Emotional State during Inactivity: The Effect of 21 Days Hypoxic Bed Rest and Confinement
Hypoxia and confinement have both been shown to influence emotional state. It is envisaged that the inhabitants of future planetary habitats will be exposed to concomitant confinement, reduced gravity and hypoxia. We examined the independent and combined effects of a 21-day inactivity/unloading and normobaric hypoxia under confined conditions on various psychological factors. Eleven healthy men...
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ژورنال
عنوان ژورنال: Journal of Experimental Biology
سال: 2014
ISSN: 1477-9145,0022-0949
DOI: 10.1242/jeb.106625